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Cortisol and IgA dropped less significantly, while IgM and IgA were increased slightly after diagnosis. ![]() Little biological correlates were found both before screening and after diagnosis. No interaction effects on biological levels between pre-post screening and esophageal pathology, anxiety states (all P > 0.05). ![]() Repeated Measures ANOVA showed that the main effects were significant on IgA levels between pre-screening and post-diagnosis ( P = 0.019). No significant differences in biological indicators were found between normal and esophagitis and low-grade intraepithelial neoplasia before screening and after diagnosis. Box–Cox-power transformation and two-way repeated measures ANOVA were used to evaluate hormone cortisol and immunoglobulin (IgA, IgG, IgM) levels in plasma, reflecting their stress, immune function, and biological correlates before screening and after knowing the diagnosis. 61 participants received twice esophageal endoscopy screening and pathological biopsy successively (with a mean follow-up of 14.03 months). Based on the national cohort of esophageal cancer program, a prospective multicenter study in high-risk regions was conducted from 2017 to 2019. The study was designed to evaluate the biological correlates of EC screening and subsequent diagnosis in China. Almost 50% of the world’s esophageal cancer (EC) cases occur in China, and the impact of cancer screening has long been a controversial topic. ![]() ![]() ![]() The software already includes a great number of templates for editing a professional DVD menu. 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